NLRP3 and infection: In terms of host cell death, human GBP5 was reported to promote NLRP3-dependent inflammasome activation in response to bacteria and soluble stimuli (Shenoyet al., 2012) and GBP1 in macrophages promotes pyroptosis duringSalmonella infection and apoptosis duringToxoplasma infection (Fischet al., 2019).