Moreover, findings on the role of AMPK in KrasG12D-driven lung cancer during glucose starvation (25), and on the KRAS-dependent transcriptional response to nutrient deprivation (45), reveal that the effects of KRAS mutations on metabolic reprogramming are also strongly influenced by the availability of nutrients which can be heterogeneously distributed within the tumor and change over time. The gene discussed is KRAS; the disease is lung cancer.