In another study in Colombia, two groups were described: first the people without any ulcer but their Leishmanin skin test were positive, the other one, infected by L. panamensis the amount of CD4+ CD25+ CD127lowTregs were determined in peripheral blood and IL-10, INF-γ and Foxp3 expression were evaluated in skin biopsies and the result indicated that the second group had more Tregs in their blood and lesions (28). Here, FOXP3 is linked to ulcer disease.