Moreover, the corresponding upstream and downstream regions were located in a target gene, TBX15. It has been demonstrated that TBX15 plays a vital role in multiple cancers, such as non–small cell lung cancer (Carvalho et al., 2013), thyroid cancer (Arribas et al., 2015), and ovarian carcinoma (Gozzi et al., 2016), and especially has been proved to be a methylation marker of prostate cancer (Kron et al., 2012). Here, TBX15 is linked to Familial prostate cancer.