Endocrine disorders are not only found in PADs, but are also common features in patients with other primary immunodeficiency diseases (PIDs), such as type 1 diabetes mellitus and thyroiditis in STAT1 gain-of function (GOF) variant (3), type 1 diabetes mellitus and short statue in STAT3 GOF variant (33), hypoparathyroidism in DiGeorge syndrome (3) and hypo(para)thyroidism and AI in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) (3). Here, STAT3 is linked to endocrine system disorder.