To compare the phenotype of male and female patients with ACTH-dependent Cushing's syndrome regarding: (1) Clinical presentation, (2) Biochemical parameters and diagnostic test results, (3) Surgical outcome (i.e., percentage remission, hydrocortisone dependency, recurrence, and mortality), and comorbidities. Here, POMC is linked to Cushing syndrome due to macronodular adrenal hyperplasia.