ALB and obesity due to melanocortin 4 receptor deficiency: The same researchers also studied the molecular mechanisms involved in this mouse phenotype; the results show that this decreased vulnerability to liver steatosis and diet-induced obesity in the ALB-D2KO mice is due to a reduction in the hepatocyte expression of liver zinc-finger protein-125 (zfp125), a FoxO1-inducible transcriptional repressor responsible for lipid accumulation through a reduced secretion of VLDL.