HNF4α and HNF1α expression is lost during liver fibrosis and HCC progression (Lazarevich et al., 2004; Lazarevich et al., 2010; Willson et al., 2013; Ni et al., 2017), while their exogenous expression triggers growth arrest in hepatoma cell lines (Lazarevich et al., 2004; Pelletier et al., 2011) and induces hepatocyte differentiation in dedifferentiated cells (Santangelo et al., 2011). Here, HNF1A is linked to hepatocellular carcinoma.