Similarly, models of hypertension can be sensitive (1 kidney/DOCA-salt, 1 kidney/DOCA, DOCA-salt, angiotensin II-salt, spontaneous hypertensive rats, dietary salt in rats, NO synthase inhibitor, cyp1a1-Ren2 hypertensive rats, capsaicin-high salt, and low renin hypertension) or insensitive (renal, e.g., following renal artery constriction; neurogenic/sympathetic nervous system, e.g., following aortic depressor plus sinus nerve ligation and vagi-aortic nerve ligation, increased dietary salt in mice, angiotensin II, and hyperaldosteronism) to TZD arterial pressure reduction (Table 1c). Here, REN is linked to hypertensive disorder.