While NDCBE-mediated TZD reduction of arterial pressure in NCC knockout mice subjected to Na+-restricted diet and NCC/pendrin double-knockout mice (Alshahrani et al., 2017a) may occur through hyponatremia, it should also be considered that hyponatremia may not accompany increased Na+ excretion. The gene discussed is SLC12A3; the disease is Hyponatremia.