This difference in NCC expression with TZD and Gitelman’s syndrome may reflect different mechanisms whereby TZD inhibit NCC activity (Payne, 2012) and of NCC dysfunction in Gitelman’s syndrome (Riveira-Munoz et al., 2007a, Riveira-Munoz et al., 2007b; Wang et al., 2015a). This evidence concerns the gene SLC12A3 and Gitelman syndrome.