Also, possibly inconsistent with the potential extrarenal TZD target in NCC knockout mice subjected to Na+-restricted diet and in NCC/pendrin double-knockout mice (Alshahrani et al., 2017a), in two patients with Gitelman’s syndrome with 8 and 25 μg hydrochlorothiazide/min/dL forearm infusion (plasma hydrochlorothiazide concentrations of 2.7 and 11.0 μM, respectively), blood flow did not increase (Pickkers et al., 1998). Here, SLC26A4 is linked to Gitelman syndrome.