However, while TZD-reduced arterial pressure in NCC knockout mice with Na+-restricted diet and an even greater pressure reduction in NCC/pendrin double-knockout mice are suggestive of an extrarenal TZD target, an involvement of hyponatremia due to NDCBE inhibition cannot be completely eliminated because of the use of supra-therapeutic TZD dose (Alshahrani et al., 2017a). This evidence concerns the gene SLC26A4 and Hyponatremia.