Hypotension associated with Gitelman’s syndrome, along with lack of hypertension despite increased renin activity and aldosterone plasma levels (Simon et al., 1996), suggest both an incomplete compensation and a prevention of increased constriction due to reduced vascular contractility (Calò et al., 1998, Calò et al., 1999; Calò, 2006). Here, REN is linked to Hypertension.