SLC12A3 and Hyponatremia: However, a caveat to this conclusion is that hydrochlorothiazide at this dose may reduce arterial pressure through hyponatremia, rather than an extrarenal target (Alshahrani et al., 2017a; [Na+/Cl– Contransporter (NCC; SLC12A3)]); and v) chronic TZD in vivo with and without additional TZD challenge of vessels isolated from these animals did not inhibit agonist constriction (Zsotér et al., 1970; Clarke et al., 1972; Sládková et al., 2007; Table 4).