(g) TZD-insensitive hypertension (“nonresponders” in humans): The TZD target should not be exposed/present in hypertensive models insensitive to TZD arterial pressure reduction (Diuresis and Plasma Volume, [Na+/Cl− Cotransporter (NCC; SLC12A3)]; Constrictor Pathways In Vivo). Here, SLC12A3 is linked to hypertensive disorder.