Acupuncture can down-regulate beta-secretase 1 (BACE1), a key enzyme affecting Aβ production, by stimulating GV14 (Deachu) and BL23 (Sinsu) of senescence-accelerated mouse prone 8 (SAMP8) mice, a rapidly aging mouse that mimics AD lesions (Dong et al., 2015). Here, BACE1 is linked to Alzheimer disease.