The miRs, miR124, miR132a and 149-5a also have anti-inflammatory effects after stroke by inhibiting CCAAT/enhanced-binding protein (C/EBP-alpha) and downstream factor PU.1, promoting microglia quiescence, and suppressing activation of microglia and consequently reducing the expression of proinflammatory cytokines and suppressing proinflammatory mediators like NFκB, TNFα, and IL6 (Wanet et al., 2012; Yu et al., 2017; Wan et al., 2018). The gene discussed is NFKB1; the disease is stroke disorder.