Perivascular macrophages and microglia play an important role in the stroke-induced inflammatory response via production of proinflammatory cytokines (IL1|upbeta TNFα IL6, IL12) and ROS (Drake et al., 2011; Liu H. et al., 2015; Wu et al., 2016; He et al., 2019). This evidence concerns the gene IL1B and stroke disorder.