Papp et al. (2012) examined the Nrf2 interactome and identified 85 miRs involved in post-transcriptional regulation of Nrf2 (Wang et al., 2016). After transient MCAO in mice, Wang et al. (2016) found a marked increase in miR93 and that a miR93 antagomir reduced brain injury. The antagomir markedly increased brain Nrf2 levels as well as hemeoxygenase-1, a protein regulated by Nrf2; i.e., miR93 acts as a repressor of Nrf2, and antagonizing its actions may be a therapeutic approach for stroke (Wang et al., 2016). The gene discussed is NFE2L2; the disease is Stroke.