Based on these theories and our research, we hypothesized that low expression of miR-375 upregulates YAP1 and activates the Hippo-YAP1 pathway, which in turn leads to 5FU efflux pumps exporting more 5FU, leaving a decreased intracellular 5FU concentration and leading to 5FU resistance in CRC. Here, YAP1 is linked to colorectal carcinoma.