YAP1 and colorectal carcinoma: As mentioned in Figure 2G, the ectopic expression of miR-375 could significantly promote cell apoptosis in chemoresistant cells, especially when combined with 5FU treatment, and the remedy assay on proliferation and apoptosis implied that YAP1 can reverse the effect of miR-375 in CRC-resistant cells (Figure 6D, 6F).