NCF1 and chronic granulomatous disease: The high prevalence of this mutation (25% of overall CGD patients) most likely originates via gene conversion from one of the two pseudogenes NCF1B and NCF1C, which also harbor the ΔGT mutation, have a sequence homology of over 99% compared with NCF1, and are in close proximity to NCF1 (Roesler et al., 2000).