Impairment of mitochondrial distribution has also been reported in an rTg4510 mouse model and in AD patient brains (Kopeikina et al., 2011), as well as in a P301L tau knockin mouse model, which has also interestingly found elevated amounts of hypophosphorylated tau (Rodríguez-Martín et al., 2016). This evidence concerns the gene MAPT and Alzheimer disease.