In the CHF group, mimics-NC group, siRNA-NC group, miR-93 mimics + OE-LIMK1 group, the mitochondria of cardiomyocytes were different in shape and size, and there were swelling, vacuolization, partial mitochondrial lysis and rupture, muscle fiber arrangement disorder, or even rupture cells. This evidence concerns the gene LIMK1 and congestive heart failure.