CASP3 and congestive heart failure: To further investigate the effect of miR-93 targeting LIMK1 gene on apoptosis-related proteins expression in CHF rats, the results showed that in contrast to the miR-93 mimics + OE-NC group, Cleaved caspase-3 and Bax protein expression levels in the miR-93 mimics + OE-LIMK1 group were obviously increased, and Bcl-2 protein expression level was dramatically decreased (all P < 0.05; Figure 8C–8F).