NPPB and congestive heart failure: To further investigate the effect of miR-93 targeting LIMK1 gene on plasma BNP, cTnI, AngII and NE in rats with CHF, the results showed that in contrast to the miR-93 mimics + OE-NC group, the levels of BNP, cTnI, AngII and NE in the plasma of the miR-93 mimics + OE-LIMK1 group were obviously increased (all P < 0.05; Figure 3A–3D).