IL6 and congestive heart failure: To further investigate the effect of miR-93 targeting LIMK1 gene on TNF-α, IL-1β, and IL-6 in plasma and myocardial tissues in rats with CHF, the results showed that in contrast to the miR-93 mimics + OE-NC group, the levels of TNF-α, IL-1β and IL-6 in the the miR-93 mimics + OE-LIMK1 group were obviously increased (all P < 0.05; Figure 4A–4C).