SOD1 and congestive heart failure: In order to further investigate the effect of miR-93 targeting LIMK1 gene on plasma oxidative stress in rats with CHF, the results showed that MDA levels were obviously increased, and SOD and T-AOC levels were dramatically decreased in the miR-93 mimics + OE-LIMK1 group relative to that in the miR-93 mimics +OE-NC group (all P < 0.05; Figure 5A–5C).