In the CHF group, mimics-NC group, siRNA-NC group, and miR-93 mimics + OE-LIMK1 group, there were obvious myocardial fibrosis, and a large amount of cardiomyocytes were necrotic, collagen composition was increased significantly, and the degree of fibrosis was obvious. This evidence concerns the gene LIMK1 and Myocardial fibrosis.