In the CHF group, mimics-NC group, siRNA-NC group, and miR-93 mimics + OE- LIMK1 group, rats’ cardiomyocytes were found swelling, necrosis, necrotic area myocardial fibrosis with inflammatory cell infiltration, myocardial cell gap increased with edema, nuclear staining, cytoplasmic vacuolization, myocardial fibers were broken and dissolved, and arranged disorderly. Here, LIMK1 is linked to Myocardial fibrosis.