Herein, miR-30c-5p not only acts as a tumor suppressor gene [25, 26], but also participates in many cellular functions: cell cycle control, DNA damage and repair, gene transcription, cell migration, invasion and apoptosis of human tumor cell by targeting downstream gene [26], including SOX9 [18, 19], Notch1 [27], Runx2 [28] and BCL9 [26]. Here, RUNX2 is linked to neoplasm.