Most patients (17/20; 85%) had also an allergy to house dust mites (HDM) with characteristic symptoms (eyes, nose and in some cases, respiratory tract) as well as positive serum IgE titres (mean titre HDM extract 47.1 kUA/L, HDM TM Der p 10 39.9 kUA/L, respectively) (Table S2). This evidence concerns the gene IGHE and allergic disease.