Overexpression of p70S6K following Raf‐1 knock‐down significantly reversed the proliferation‐suppressing effects of Raf‐1 depletion (Figure 2B, shRaf‐1 + OE‐p70S6K), indicating that p70S6K mediates the critical effect of Raf‐1 in sustaining NSCLC cell proliferation. This evidence concerns the gene RPS6KB1 and non-small cell lung carcinoma.