GC and asthma: Contrarily, VDBP GC1s have been proposed as a protective factor for the progression of asthma when compared to GC1f/1f genotype in the Hispanic population.35 More recently, Fawzy et al 36 observed that GG genotype and G allele of the VDBP rs7041 are a potential risk factor for asthma development, while rs4588 AA genotype and A allele had a protection role in that study.