MAPK8 and Stroke: The current data demonstrate that (a) JNK‐IN‐8 inhibits the activation of JNK‐NK‐κB pathway, (b) JNK‐IN‐8 inhibits microglia activation in vivo after ischemic stroke, (c) JNK‐IN‐8 inhibits microglia activation and proinflammatory cytokines production in vitro, (d) JNK‐IN‐8 improves functional recovery after stroke.