Genetic variations of the exons in the REG1A gene have been examined in small numbers of studies using a combination of restriction fragment length polymorphism (RFLP), single-strand conformation polymorphism (SSCP) and sequencing techniques, and no mutations were identified in the coding regions of REG1Α gene and to be associated with the development and progression of several types of pancreatic diseases [28, 29]. Here, ZC3H12A is linked to pancreas disorder.