Our observation that GLP2 was positively associated with osteocalcin in the women without osteoporosis is consistent with the increase in osteocalcin previously observed in post-menopausal women after the subcutaneous administration of GLP2 under fasting conditions52 and also with the aforementioned report on increased osteocalcin in osteoblast cell lines after GLP2 treatment37. This evidence concerns the gene GCG and osteoporosis.