However, when diabetes was induced, mice with a global over-expression of OST48 had significant reduction in fractional glucose excretion (Fig. 4A), increases in fasting plasma insulin (Fig. 4B) and lower blood glucose concentrations during an ipGTT, both acutely at 15 minutes (11.9% decrease, P = 0.097) and 30 minutes (14.2% decrease, P = 0.017) post-bolus of D-glucose (Fig. 4C). Here, INS is linked to diabetes mellitus.