As a member of a family of chromatin remodelers with putative roles in senescence41,44,69,70, repression of tumor suppressor genes41,44, stem cell control38,45,48,51, Hox gene control71, and DNA repair72, our identification of HELLS upregulation in medulloblastoma could be an important finding. The gene discussed is HELLS; the disease is medulloblastoma.