DNASE1L3 and systemic lupus erythematosus: In patients with SLE, Shin et al. 11 demonstrated that the frequency of the homozygote for the G allele corresponding to Arg244 was much higher in individuals possessing the autoantibodies than in patients who did not, being partly attributable to production of the low activity-harboring DNase I isoform by the G allele in SNP p.Gln244Arg.