We chose these proteins for validation since they are involved in essential functional pathways of cancer cells: GMPPA is glycosylation catalytic enzymes37, RRM2 catalyzes the biosynthesis of deoxyribonucleotide38, MAVS acts in innate immune defense39, and SOD1 regulates the reactive oxygen stress by destroying superoxide radicals40. This evidence concerns the gene GMPPA and cancer.