Interestingly, cardiac-specific YY1 knockout mice (YY1f/f-Nkx2.5Cre) displayed very similar phenotypes as Tet2/3-DKO mice generated in the current study, with both in vivo models showing reduced embryo survival at E13.5 and decreased proliferation of CMs (with similar non-compaction cardiomyopathy manifestations)52. Here, YY1 is linked to non-compaction cardiomyopathy.