Interestingly, humans express an ortholog (86% identity) of this circRNA (Fig. 1f), and we found that expression of the human circFndc3b ortholog was also significantly reduced in the LV tissues of ischemic cardiomyopathy patients compared to non-failing hearts (Fig. 1g), unlike the linear Fndc3b mRNA (Supplementary Fig. 2C–D). The gene discussed is FNDC3B; the disease is ischemic cardiomyopathy.