However, using the wt p53 MCF7 breast cancer cells, we only observed a minor LC3-II induction in response to CP-31398 in comparison to p53-mutated cells, which seems to be insufficient to increase MCF7 lysis by NK cells and suggesting that the induction of autophagy using this small compound is mostly effective in p53-mutated cells. The gene discussed is TP53; the disease is breast carcinoma.