NR4A1 and Parkinson disease: Murine Nr4a1 genetic deletion is associated with an increase in tyrosine hydroxylase, dopamine turnover (Gilbert et al., 2006), baseline locomotor activity (Gilbert et al., 2006; Rouillard et al., 2018), and tardive dyskinesia (Ethier et al., 2004), but a reduction in levodopa induces dyskinesia [levodopa-induced dyskinesia (LID)] in both rodent and nonhuman primate models of Parkinson’s disease (St-Hilaire et al., 2003a,b; Mahmoudi et al., 2009, 2013).