Others have shown that synovium T effectors are resistant to Treg suppression,20 which can be alleviated in patients with JIA undergoing anti-TNFα therapy.37 Though it is noted that in a subset of patients, in vitro blockade of IL-6+ additionally alleviated T-effector resistance to Treg suppression.37 The gene discussed is TNF; the disease is juvenile idiopathic arthritis.