Previous reports have shown that GCs increased SGK1 expression in human neural stem cell, whereas an inhibitor of SGK1 hampered the glucocorticoid-induced reduction in neurogenesis, suggesting that SGK1 mediated the effects of GCs on glucocorticoid receptor function and neurogenesis and may be a key intermediary between stress and depression [11,28]. Here, SGK1 is linked to major depressive disorder.