TP53 and neoplasm: In tumor cells possessing genetic defects in sensor or repair proteins, incomplete DNA repair would trigger cell death signaling associated with the p53-dependent expressions of proapoptotic proteins such as PUMA, phorbol-12-myristate-13-acetate-induced protein 1 (also known as NOXA) and Bcl2-associated X protein (Bax) [55,56,57].