The inhibitory effect of overexpressed miR-21 on TMZ-induced apoptosis was described in other GBM cell line, U87MG, where it was mediated through downregulation of proapoptotic proteins, Bax and caspase-3, as well as via upregulation of antiapoptotic protein Bcl-2 [22]. The gene discussed is CASP3; the disease is glioblastoma.