CHEK2 and neurodegenerative disease: Several studies have reported a beneficial potential of 1: a checkpoint kinase 2 (Chk2) inhibitor that arrests cell cycles involved in DNA repair or apoptosis in cancerous cells [15,16]; the inhibition of human immunodeficiency virus 1 (HIV-1) [17]; antifouling activity against the green mussel Perna viridis and the bryozoan Bugula neritina [18]; the inhibition against the kinase targets of neurodegenerative disease, CDK5/p25, CK2d, and GSK3b; and potent antibacterial activity [19].