Especially, IL4Rα+IL13Rα1+ subgroup of CCRCC significantly associated with larger tumor size, higher tumor stage, and lymph node metastasis, and predicted a 3.2-fold greater risk of death of CCRCC patients compared with IL4Rα−IL13Rα1−/IL4Rα−IL13Rα1+/IL4Rα+IL13Rα1− subgroups (Table 1 and Table 3). This evidence concerns the gene IL4R and neoplasm.