For example, SDF-1/CXCR4 plays roles in immune [34], hematopoietic [35], brain development [36], angiogenesis [37,38], HIV-1 infection [39], autoimmune diseases [34,40], cancer [41,42], inflammation [43] and other pathological processes [44]. This evidence concerns the gene CXCR4 and HIV-1 infection.