ADCYAP1R1 and Anxiety: The stress-response related brain regions (i.e., bed nucleus of stria terminalis—BNST, amygdala complex, hippocampus, and medial prefrontal cortex) were shown to express both PACAP1-38 and PAC1-R suggesting a role in stress, anxiety, and fear-related learning [182,183,184,185,186] through PACAP1-38-containing fibers that innervated CRH-expressing neurons in the paraventricular nucleus and BNST [187].