Treatment with 0–50 μM EGCG has been shown to prevent the proliferation of PC3 PCa cell lines with an IC50 value of 39 μM, via the activation of extracellular signal-regulated kinase (ERK1/2), independently of mitogen-activated protein kinase kinase (MEK) signalling [106]. Here, MAPK3 is linked to posterior cortical atrophy.