FASN and posterior cortical atrophy: However, more recently the treatment of LNCaP and castration-resistant (22Rv1) human PCa cells with SFN has shown to downregulate fatty acid (FA) metabolism proteins, including those involved in FA synthesis (acetyl-CoA carboxylase 1 (ACC1) and fatty acid synthase (FASN)) and FA uptake for β-oxidation (carnitine palmitoyltransferase 1A, CPT1A).