MMP9 and neoplasm: Besides secreted cytokines, enzymes were also described to be significantly involved in neoangiogenesis/tumor growth, including MMP9, which is mainly produced by tumor-infiltrating myeloid cells, and cyclo-oxygenase-2 (Cox-2), which is known for producing eicosanoide inflammatory mediators under pathologic conditions, with little if any contribution to developmental vessel formation [4,76].