Recently, a novel strategy aimed at simultaneous Tie-2 activation and Ang-2 inhibition with ABTAA (Ang2-binding and Tie-2-activating antibody) has been shown to result in the normalization of tumor vasculature, decreased hypoxia, acidosis, tumor growth and metastasis, with a favorable tumor microenvironment also enabling the enhanced delivery of chemotherapeutic agents into tumors [162]. This evidence concerns the gene ANGPT2 and neoplasm.