Among genes down-regulated by the constitutive activation of BRAF pathway, there are several tumor suppressor genes involved in numerous cellular processes, such as metallopeptidase inhibitor 3 (TIMP3), sodium-coupled monocarboxylate transporter 1 (SLC5A8), death-associated protein kinase (DAPK), b2 retinoic acid receptor (RARb2) and their silencing by promoter hypermethylation represents an important molecular mechanism in tumor progression [42]. The gene discussed is SLC5A8; the disease is neoplasm.