C5AR1 and metabolic dysfunction-associated steatohepatitis: Figure 3 shows that the onset of NASH in mice fed for one week with the MCD diet was characterized by an upregulation in liver CX3CR1 transcript and by an increase in CD11b+ myeloid HDCs that co-expressed CX3CR1, CD88 and Ly6C, suggesting that moDCs might also account for HDC activation associated with steatohepatitis.