Indeed, we demonstrated that the genetic reduction [64,65] or ablation [66] of mGluR1 or mGluR5 in SOD1G93A mice positively affects the disease course in SOD1G93A mice, prolonging survival, ameliorating motor skills, and improving biochemical and cellular parameters that are altered during the progression of ALS. This evidence concerns the gene GRM5 and amyotrophic lateral sclerosis.