In summary, the HLA-DQB1*02, HLA-DRB1*03, DRB1*04, and DRB1*09 allele groups may predispose individuals to LADA; HLA-DQB1*06 and DQB1*05 have protective effects against the development of LADA; and HLA-DQB1*03, HLA-DQB1*04, HLA-DRB1*10, HLA-DRB1*11, HLA-DRB1*14, HLA-DRB1*15, and HLA-DRB1*16 may not play a role in this disease. Here, HLA-DRB1 is linked to latent autoimmune diabetes in adults.