PRDM9 and Ehlers-Danlos syndrome, musculocontractural type: Additional alterations occurring in advanced follicular-derived thyroid cancer concern: (i) Members of the DNA Mismatch Repair pathway (MSH2, MSH6, and MLH1), mutated in 2% of PDTCs and 12% of ATCs that induce a “hypermutator phenotype”; (ii) histone methyl-transferases (HMTs), altered in 7% of PDTCs and 24% of ATCs; (iii) genes encoding for members of the SWI-SNF chromatin remodeling complex, mutated in 6% of PDTCs and 36% of ATCs [39].