CAPN3 and muscular dystrophy, limb-girdle, autosomal dominant 4: Recently, heterozygous mutations in the CAPN3 gene have been reported to cause autosomal dominant limb-girdle muscular dystrophy-4 (LGMDD4), with a later onset and milder phenotype [43,44,45], although the mechanisms underlying these cases still need some clarification [46].