CAPN3 and limb-girdle muscular dystrophy: The prevalence of LGMDR1 ranges from 1 to 9 cases per 100,000 people, and it represents almost 30% of all LGMD cases in open populations [47,48,49,50,51,52,53] with some ancestral mutations responsible for specific ethnic or geographic clusters [54,55,56,57,58].