The most frequently mutated genes were DNMT3a, NPM1, and ASXL1 in AML; ASXL1, SRSF2, and RUNX1 in MDS; JAK2 and CALR in MPN; and ASXL1, TET2, and SRSF2 in MDS/MPN. The gene discussed is DNMT3A; the disease is myelodysplastic syndrome.