Although single agent Ipilimumab (an anti-CTLA-4 monoclonal antibody) immunotherapy was shown in a phase 2 study ineffective in the treatment of advanced pancreatic cancer, it might be considered when combination chemotherapy with nab-paclitaxel and gemcitabine is applied, as this regimen decreased the number of CAFs in the treatment of pancreatic cancer [109,110]. Here, CTLA4 is linked to pancreatic neoplasm.