HSF1 and hepatocellular carcinoma: Furthermore, reduced mRNA levels associated with lipogenesis (fas, acc, and scd1) and lipogenic factors (srebp1c, pparγ1, pparγ2, and c/ebpβ) were observed in diethylnitrosamine (DEN)-induced hepatic steatosis and hepatocellular carcinoma (HCC) model-driven HSF1 knock-out mice [27].