HMGCR and hepatocellular carcinoma: To understand the universality of suppressive effects of KRIBB11 on cholesterol biosynthesis gene expression in other cancer types, we measured mRNA levels of 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) and farnesyl diphosphate synthase (FDPS) in the absence or presence of KRIBB11 upon lipoprotein depletion in H1299 (non-small cell lung carcinoma), HCT116 (colorectal carcinoma), and A2058 (malignant melanoma) cells and found that KRIBB11 decreased HMGCR and FDPS mRNA levels induced by lipoprotein depletion in three type of cells as well as HCC cells (Figure 1E).