SQLE and cancer: Interestingly, previous work has shown that a gain-of-function mutant of p53 enhances the mRNA expression of genes associated with the mevalonate pathway and cholesterol biosynthesis, such as HMGCR, mevalonate kinase (MVK), farnesyl diphosphate synthase (FDPS), and squalene epoxidase (SQLE), by cooperating with SREBP2, resulting in the promotion of cancer progression [47,48].