Interestingly, recent works have shown that HSF1 is a critical factor for the growth of AKT and c-MYC-driven hepatocellular carcinoma through the maintenance of lipogenesis and cholesterol metabolism [28,29]; however, the functional role of HSF1 and its regulatory mechanisms in the mevalonate pathway and cholesterol biosynthesis have not been elucidated in-depth. Here, MYC is linked to hepatocellular carcinoma.