AKT1 and cancer: The hyperactivation of the oncogenic PI3K-AKT and RAS-MAPK growth signaling pathways, considered a hallmark of cancer, is driven by gain-of-function mutations, allowing for cell proliferation and survival and subsequently resulting in the development and progression of multiple types of cancer; however, the precise molecular mechanism by which RAS-MAPK activates cholesterol biosynthesis is not clearly understood.