IGF2BP3 and neoplasm: In addition, Fu and colleagues [70] reported that AVA 2p treatment down-regulated other two targets of the tumor suppressor miR-129-3p: IGF2BP3 (insulin like growth factor 2 mRNA binding protein 3) and CDK6 (cyclin-dependent kinase 6), both important for G1-phase progression and G1/S-transition [81].